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Advion Adds Plavix LC/MS Method

New method aids in CV comparative and drug-drug interaction studies

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By: Tim Wright

Editor-in-Chief, Contract Pharma

Advion BioServices has added clopidogrel, plus its active metabolite and its inactive carboxylic acid metabolite, to its list of validated LC/MS methods. The addition was made due to market demand for this bioanalytical method.

Clopidogrel, commonly known as Plavix, is used to prevent blood clots that can lead to heart attacks and strokes. According to the Mayo Clinic, heart disease is the number one killer of men and women worldwide, and the primary form of treatment is a prescribed oral medicine such as clopidogrel.

When a drug is commonly prescribed and often co-administered, it is important for pharmaceutical companies and doctors to understand how the drugs will interact with other classes of drugs byconducting crossover comparison studies. This is especially important for drugs such as clopidogrel, where the active form of the drug is generated by cytochrome P450-mediated biotransformation. Advion is one of a few CROs in the world offering bioanalytical assays specific for clopidogrel to support these studies.

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